旧秩序阿米什人中血浆新蝶呤水平的遗传力。
Heritability of plasma neopterin levels in the Old Order Amish.
作者信息
Raheja Uttam K, Fuchs Dietmar, Lowry Christopher A, Stephens Sarah H, Pavlovich Mary A, Mohyuddin Hira, Yousufi Hassaan, Ryan Kathleen A, O'Connell Jeff, Brenner Lisa A, Punzalan Cecile, Hoisington Andrew J, Nijjar Gursharon K, Groer Maureen, Shuldiner Alan R, Pollin Toni I, Stiller John W, Mitchell Braxton D, Postolache Teodor T
机构信息
Mood and Anxiety Program, University of Maryland School of Medicine, 685 W. Baltimore Street, Suite# 930, Baltimore, MD 21201, USA; Child and Adolescent Psychiatry Residency Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Drive, Atlanta, GA 30329, USA.
Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innrain 80, 6020, Innsbruck, Austria.
出版信息
J Neuroimmunol. 2017 Jun 15;307:37-41. doi: 10.1016/j.jneuroim.2017.02.016. Epub 2017 Feb 22.
BACKGROUND
We examined the heritability of neopterin, a biomarker for cell-mediated immunity and oxidative stress, and potentially for psychiatric disorders, in the Old Order Amish.
METHODS
Plasma neopterin levels were determined in 2015 Old Order Amish adults. Quantitative genetic procedures were used to estimate heritability of neopterin.
RESULTS
Heritability of log-neopterin was estimated at 0.07 after adjusting for age, gender, and household (p=0.03). The shared household effect was 0.06 (p<0.02).
CONCLUSIONS
We found a low heritability of neopterin and small household effect, suggesting that non-household environmental factors are more important determinants of variance of neopterin levels in the Amish.
背景
我们研究了新蝶呤的遗传力，新蝶呤是细胞介导免疫和氧化应激的生物标志物，可能与精神疾病有关，研究对象为旧秩序阿米什人。
方法
测定了2015名旧秩序阿米什成年人的血浆新蝶呤水平。采用定量遗传学方法估计新蝶呤的遗传力。
结果
在调整年龄、性别和家庭因素后，对数新蝶呤的遗传力估计为0.07（p=0.03）。家庭共同效应为0.06（p<0.02）。
结论
我们发现新蝶呤的遗传力较低，家庭效应较小，这表明非家庭环境因素是阿米什人中新蝶呤水平变异的更重要决定因素。
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