Department of Biomedical Sciences, School of Medicine, University of Sassari, Sassari, Italy.
Department of Biomedical Sciences, School of Medicine, University of Sassari, Sassari, Italy.
Exp Gerontol. 2017 Dec 1;99:133-137. doi: 10.1016/j.exger.2017.10.005. Epub 2017 Oct 9.
In addition to viral infections, malignant disorders, autoimmune diseases, and allograft rejection episodes, neopterin increases in older people where it is found to be predictive of overall mortality. Thus, the serum concentrations of this biomarker of systemic immune and inflammation activation, were measured in a small cohort of Sardinian middle-aged, older adults and centenarians. There was a significant positive correlation between neopterin concentrations and age with the subjects in the 95-year-old group with the highest values. Notably, the group of centenarians had neopterin values comparable to those of 80- and 90-year-old groups, and significantly lower than that of 95-year-old group. This suggests a decreased monocyte/macrophage-mediated immune activation and an apparently preserved immune status in centenarians.
除了病毒感染、恶性疾病、自身免疫性疾病和同种异体移植排斥反应外，新蝶呤在老年人中也会增加，并且被发现可以预测总死亡率。因此，我们在一小群撒丁岛中年、老年和百岁老人中测量了这种全身免疫和炎症激活的生物标志物的血清浓度。新蝶呤浓度与年龄呈显著正相关，95 岁组的受试者浓度最高。值得注意的是，百岁老人组的新蝶呤值与 80 岁和 90 岁组相当，显著低于 95 岁组。这表明百岁老人的单核细胞/巨噬细胞介导的免疫激活减少，免疫状态明显得到保留。
