雄蝇的性别由决定，它是通用剪接因子基因的一个旁系同源基因。

Male sex in houseflies is determined by , a paralog of the generic splice factor gene .

机构信息

Groningen Institute for Evolutionary Life Sciences, University of Groningen, Post Office Box 11103, 9700 CC, Groningen, Netherlands.

Institute of Molecular Life Sciences, University of Zurich, CH-8057 Zurich, Switzerland.

出版信息

Science. 2017 May 12;356(6338):642-645. doi: 10.1126/science.aam5498.

DOI:10.1126/science.aam5498

PMID:28495751

Abstract

Across species, animals have diverse sex determination pathways, each consisting of a hierarchical cascade of genes and its associated regulatory mechanism. Houseflies have a distinctive polymorphic sex determination system in which a dominant male determiner, the M-factor, can reside on any of the chromosomes. We identified a gene, (), as the M-factor. originated from a duplication of the spliceosomal factor gene (). Targeted disruption results in complete sex reversal to fertile females because of a shift from male to female expression of the downstream genes and The presence of on different chromosomes indicates that translocated to different genomic sites. Thus, an instructive signal in sex determination can arise by duplication and neofunctionalization of an essential splicing regulator.

摘要

在不同物种中，动物有多种性别决定途径，每种途径都由基因及其相关调控机制的层次级联组成。家蝇具有独特的多态性别决定系统，其中显性雄性决定因子 M 因子可以存在于任何染色体上。我们鉴定了一个基因，（），作为 M 因子。它起源于剪接因子基因（）的重复。靶向破坏导致完全性别逆转为可育雌性，因为下游基因（）和（）的表达从雄性转变为雌性。不同染色体上存在（）表明（）已易位到不同的基因组位点。因此，通过必需剪接调节剂的复制和新功能化，可以产生性别决定的指导信号。