Wlodek M E, Challis J R, Patrick J
Department of Obstetrics & Gynecology, University of Western Ontario, London, Canada.
J Dev Physiol. 1988 Aug;10(4):309-19.
A chronic fetal sheep preparation was developed to measure, without interruption in utero, urethral and urachal urine output to the amniotic and allantoic sacs, respectively. Fetal urethral, urachal and total urine output was measured during a 5 day post-operative period, in late gestation. Total fetal urine output increased from day 1 to a volume of 1216 +/- 115 ml/day (SEM) on day 5 post-operative. Urachal urine output increased significantly from 12 ml/day on day 1 to 467 ml/day on day 5 (P less than 0.05). Fetal arterial blood gases, pH and immunoreactive ACTH, cortisol and immunoreactive arginine vasopressin concentrations were stable throughout the 5-day recovery period. Fetal urachal urine output to the allantoic cavity and total fetal urine output appears to require 4-5 days to stabilize post-operatively. Fetal urine is a major source of amniotic and allantoic fluid in late gestation and the volume of these sacs may be influenced, in part, by the distribution of urethral and urachal urine output.
开发了一种慢性胎儿绵羊制备方法，用于在子宫内不间断地测量分别进入羊膜囊和尿囊的尿道和脐尿管尿量。在妊娠后期的术后5天期间测量胎儿尿道、脐尿管和总尿量。术后第1天至第5天，胎儿总尿量从每天增加到1216±115毫升/天（标准误）。脐尿管尿量从第1天的每天12毫升显著增加到第5天的467毫升/天（P<0.05）。在整个5天的恢复期内，胎儿动脉血气、pH值以及免疫反应性促肾上腺皮质激素、皮质醇和免疫反应性精氨酸加压素浓度均保持稳定。术后胎儿脐尿管进入尿囊的尿量和胎儿总尿量似乎需要4至5天才能稳定。胎儿尿液是妊娠后期羊膜液和尿囊液的主要来源，这些囊的体积可能部分受尿道和脐尿管尿量分布的影响。
