Power S, Patrick J E, Challis J R
J Dev Physiol. 1980 Dec;2(6):357-63.
The disposition of [3H]cortisol was determined after an intraamniotic injection into chronically catheterized sheep between days 120 and 146 of pregnancy. [3H]Cortisol disappeared from amniotic fluid with a half-life of 55.6 +/- 10.8 (SEM) min. Radioactivity, identified as [3H] cortisol appeared in allantoic fluid, fetal blood and tracheal fluid. The concentration of [3H]cortisol in allantoic fluid rose such that it approached that found in amniotic fluid at 60 min after injection. The highest concentration of [3H]cortisol in fetal blood was found 15 min after injection. The time-course for appearance of [3H]cortisol into tracheal fluid was variable, but in individual experiments peak values were found 45-150 min after injection. We conclude that during late gestation, cortisol in amniotic fluid is readily accessible to the allantoic fluid and to the fetus.
在妊娠120至146天期间，对长期插管的绵羊进行羊膜腔内注射[3H]皮质醇后，测定了[3H]皮质醇的处置情况。[3H]皮质醇从羊水消失，半衰期为55.6±10.8（标准误）分钟。鉴定为[3H]皮质醇的放射性出现在尿囊液、胎儿血液和气管液中。尿囊液中[3H]皮质醇的浓度升高，以至于在注射后60分钟接近羊水中的浓度。胎儿血液中[3H]皮质醇的最高浓度在注射后15分钟出现。[3H]皮质醇进入气管液的时间进程各不相同，但在个别实验中，在注射后45 - 150分钟出现峰值。我们得出结论，在妊娠后期，羊水内的皮质醇很容易进入尿囊液和胎儿体内。
