Margolis H S, Nainan O V, Krawczynski K, Bradley D W, Ebert J W, Spelbring J, Fields H A, Maynard J E
Hepatitis Branch, Centers for Disease Control, Atlanta, Georgia 30333.
J Med Virol. 1988 Nov;26(3):315-26. doi: 10.1002/jmv.1890260311.
Circulating immune complexes (CICs) were detected during the course of experimental hepatitis A virus (HAV) infection in 8 of 9 chimpanzees. In all cases, the predominant class of antibody detected in the CIC was IgM. The appearance of IgM-CIC usually preceded the onset of liver enzyme elevations, and in all instances, the appearance of IgM-CIC correlated with the presence of IgM anti-HAV. Six of 8 animals tested had significant depression of C3 concentrations during the course of infection, and this depression occurred at the peak of CIC activity. Immunohistologic studies demonstrated granular deposits of IgM localized in sinusoidal cells during peak of IgM-CIC activity. IgM-CICs appear to be a fairly consistent finding during HAV infection and probably represent the viremic phase of the disease. However, they do not appear to mediate hepatocellular injury by direct action on hepatocytes.
在9只黑猩猩的实验性甲型肝炎病毒（HAV）感染过程中，检测到8只黑猩猩体内存在循环免疫复合物（CIC）。在所有病例中，CIC中检测到的主要抗体类别为IgM。IgM - CIC的出现通常先于肝酶升高，并且在所有情况下，IgM - CIC的出现与IgM抗 - HAV的存在相关。8只接受检测的动物中有6只在感染过程中C3浓度显著降低，且这种降低发生在CIC活性的峰值阶段。免疫组织学研究表明，在IgM - CIC活性峰值时，IgM颗粒状沉积物定位于窦状细胞中。IgM - CIC似乎是HAV感染过程中一个相当一致的发现，可能代表了该疾病的病毒血症阶段。然而，它们似乎并非通过直接作用于肝细胞来介导肝细胞损伤。
