感染人甲型肝炎病毒的恒河猴（猕猴）甲型肝炎实验模型

[Experimental model of hepatitis A in rhesus monkeys (Macaca mulatta) infected with human hepatitis A virus].

作者信息

Shevtsova Z V, Krylova R I, Doroshenko N V, Lomovskaia I B, Belova E G, Zairov G K, Dzhelieva Z N, Lapin B A, Stakhanova V M

出版信息

Biull Eksp Biol Med. 1990 Jun;109(6):536-9.

PMID:2168770

Abstract

The focus of this paper is characterization of Hepatitis A experimental model obtained for the first time in rhesus monkeys (M. mulatta) infected with fecal isolate from a patient with Hepatitis A (HAV-H1). Monkeys were susceptible to oral and intravenous routes of HAV inoculation. The disease could be reproduced regularly in 4 passages as a result of which HAV strain continuously pathogenic for M. mulatta has been established. All 17 infected monkeys developed Hepatitis A with characteristic (except jaundice) patterns: shedding of virus with the stool, elevations of serum alanine aminotransferase level, appearance of IgM anti-HAV, morphological changes developed in the liver. Our data have demonstrated that the course of experimental Hepatitis A infection in M. mulatta is similar (in many respects) to that observed in man.

摘要

本文的重点是对首次在感染甲型肝炎患者（HAV-H1）粪便分离株的恒河猴（M. mulatta）中获得的甲型肝炎实验模型进行表征。猴子对甲型肝炎病毒的口服和静脉接种途径敏感。该疾病可在4代中定期重现，由此建立了对恒河猴持续致病的甲型肝炎病毒株。所有17只感染的猴子都出现了具有特征性（除黄疸外）的甲型肝炎症状：粪便中排出病毒、血清丙氨酸转氨酶水平升高、出现IgM抗-HAV、肝脏出现形态学变化。我们的数据表明，恒河猴实验性甲型肝炎感染的过程（在许多方面）与人中观察到的相似。