Farzanehfar Vahid, Faizi Mehrdad, Naderi Nima, Kobarfard Farzad
Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Pharm Res. 2017 Winter;16(1):140-145.
Dibutyl phthalate (DBP) is a phthalic acid ester and is widely used in polymeric products to make them more flexible. DBP is found in almost every plastic material and is believed to be persistent in the environment. Various analytical methods have been used to measure DBP in different matrices. Considering the ubiquitous nature of DBP, the most important challenge in DBP analyses is the contamination of even analytical grade organic solvents with this compound and lack of availability of a true blank matrix to construct the calibration line. Standard addition method or using artificial matrices reduce the precision and accuracy of the results. In this study a surrogate analyte approach that is based on using deuterium labeled analyte (DBP-d4) to construct the calibration line was applied to determine DBP in hexane samples.
邻苯二甲酸二丁酯（DBP）是一种邻苯二甲酸酯，广泛用于聚合物产品中以使其更具柔韧性。几乎在每种塑料材料中都能发现DBP，并且据信它在环境中具有持久性。已使用各种分析方法来测量不同基质中的DBP。考虑到DBP无处不在的特性，DBP分析中最重要的挑战是即使是分析纯的有机溶剂也会被这种化合物污染，并且缺乏用于构建校准曲线的真正空白基质。标准加入法或使用人工基质会降低结果的精密度和准确度。在本研究中，采用了一种基于使用氘标记分析物（DBP-d4）构建校准曲线的替代分析物方法来测定己烷样品中的DBP。
