人类慢性心房颤动中兴奋-收缩偶联的改变
Altered Excitation-Contraction Coupling in Human Chronic Atrial Fibrillation.
作者信息
Grandi Eleonora, Workman Antony J, Pandit Sandeep V
机构信息
Department of Pharmacology, University of California at Davis, Davis, CA, USA.
Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK.
出版信息
J Atr Fibrillation. 2012 Apr 14;4(6):495. doi: 10.4022/jafib.495. eCollection 2012 Apr-May.
Abstract
This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory period, depressed intracellular Ca transient, and reduced myocyte contractility. Here we summarize the current knowledge of the ionic bases underlying these changes. Understanding the molecular mechanisms of excitation-contraction-coupling remodeling in the fibrillating human atria is important to identify new potential targets for AF therapy.
摘要
本综述聚焦于慢性心房颤动患者心房兴奋-收缩偶联中的（适应不良）适应性过程。细胞重塑包括心房动作电位时程缩短和有效不应期缩短、细胞内钙瞬变降低以及心肌细胞收缩力减弱。在此，我们总结了这些变化背后离子基础的当前知识。了解颤动人心房兴奋-收缩偶联重塑的分子机制对于确定房颤治疗的新潜在靶点很重要。
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