Department of Pharmacology, University of California at Davis, Davis, CA 95616-8636, USA.
Trends Cardiovasc Med. 2011 Jul;21(5):145-50. doi: 10.1016/j.tcm.2012.04.004.
Computational electrophysiology has proven useful to investigate the mechanisms of cardiac arrhythmias at various spatial scales, from isolated myocytes to the whole heart. This article reviews how mathematical modeling has aided our understanding of human atrial myocyte electrophysiology to study the contribution of structural and electrical remodeling to human atrial fibrillation. Potential new avenues of investigation and model development are suggested.
计算电生理学已被证明在从分离的心肌细胞到整个心脏的各种空间尺度上研究心律失常机制是有用的。本文综述了数学建模如何帮助我们理解人心房肌细胞电生理学，以研究结构和电重构对人类心房颤动的贡献。还提出了一些潜在的新的研究和模型开发途径。
