Nodari Savina, Triggiani Marco, Campia Umberto, Dei Cas Livio
Department of Experimental and Applied Medicine-Section of Cardiovascular Diseases, University of Brescia, Brescia, Italy.
Northwestern University Feinberg School of Medicine, Chicago (IL), US.
J Atr Fibrillation. 2012 Dec 16;5(4):718. doi: 10.4022/jafib.718. eCollection 2012 Dec.
Atrial fibrillation (AF) is the most prevalent arrhythmia and is associated with considerable morbidity and mortality. Available pharmacologic antiarrhythmic therapies are often ineffective in preventing the recurrence of AF, possibly because these drugs target a single pathophysiological mechanism. Given their beneficial effects on ventricular arrhythmias, omega-3 polyunsaturated fatty acids (n-3 PUFAs) have recently been investigated as possible candidates in the treatment of supraventricular arrhythmias. In this review, we explore the current understanding of the antiarrhythmic effects attributed to n-3 PUFAs including direct modulation of ionic channels, improvement of membrane fluidity, anti-inflammatory and antifibrotic effects, and modulation of sympatho-vagal balance. We will then focus on the results of epidemiologic studies exploring the associations between nutritional intake of n3 PUFAs and the incidence of AF, and will review the findings of the clinical trials investigating the effects of n-3 PUFAs supplementation in the prophylaxis of AF and in the prevention of its recurrences.
心房颤动（AF）是最常见的心律失常，与相当高的发病率和死亡率相关。现有的抗心律失常药物治疗往往在预防房颤复发方面无效，这可能是因为这些药物针对单一的病理生理机制。鉴于ω-3多不饱和脂肪酸（n-3 PUFAs）对室性心律失常有有益作用，最近它们被作为治疗室上性心律失常的可能候选药物进行了研究。在这篇综述中，我们探讨了目前对n-3 PUFAs抗心律失常作用的理解，包括对离子通道的直接调节、膜流动性的改善、抗炎和抗纤维化作用以及交感-迷走神经平衡的调节。然后，我们将重点关注探索n-3 PUFAs营养摄入量与房颤发病率之间关联的流行病学研究结果，并回顾调查补充n-3 PUFAs在预防房颤及其复发方面效果的临床试验结果。
