类风湿关节炎中的滑膜细胞和分子标志物
Synovial cellular and molecular markers in rheumatoid arthritis.
作者信息
Asif Amin M, Fox David A, Ruth Jeffrey H
机构信息
Division of Rheumatology and the Clinical Autoimmunity Center of Excellence, University of Michigan, Ann Arbor, MI, USA.
出版信息
Semin Immunopathol. 2017 Jun;39(4):385-393. doi: 10.1007/s00281-017-0631-3. Epub 2017 May 11.
Abstract
The profound alterations in the structure, cellular composition, and function of synovial tissue in rheumatoid arthritis (RA) are the basis for the persistent inflammation and cumulative joint destruction that are hallmarks of this disease. In RA, the synovium develops characteristics of a tertiary lymphoid organ, with extensive infiltration of lymphocytes and myeloid cells. Concurrently, the fibroblast-like synoviocytes undergo massive hyperplasia and acquire a tissue-invasive phenotype. In this review, we summarize key components of these processes, focusing on recently-described roles of selected molecular markers of these cellular components of RA synovitis.
摘要
类风湿关节炎（RA）中滑膜组织的结构、细胞组成和功能发生的深刻改变，是该疾病持续性炎症和累积性关节破坏的基础，而这些正是该疾病的标志。在RA中，滑膜呈现出三级淋巴器官的特征，有淋巴细胞和髓样细胞大量浸润。同时，成纤维样滑膜细胞大量增生并获得组织侵袭性表型。在本综述中，我们总结了这些过程的关键组成部分，重点关注最近描述的RA滑膜炎这些细胞成分的特定分子标志物的作用。
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