Wei T-T, Wang L-L, Yin J-R, Liu Y-T, Qin B-D, Li J-Y, Yin X, Zhou L, Zhong R-Q
Department of Laboratory Medcine, Changzheng Hospital, The Second Military Medical University, Shanghai, China.
Int J Lab Hematol. 2017 Oct;39(5):497-501. doi: 10.1111/ijlh.12675. Epub 2017 May 12.
Red blood cell distribution width (RDW) and bilirubin have been proved to be prognostic factors for various types of cancer. However, their prognostic value in patients with gastric cancer (GC) remains largely unknown.
To verify whether RDW and bilirubin are prognostic factors for patients with GC, we performed a cross-sectional study to analyze the relationship between RDW, bilirubin, and the clinical characteristics of patients with GC. Medical records of all newly diagnosed and pathologically proved patients with GC admitted to Changzheng Hospital between January 2016 and July 2016 were retrospectively reviewed. The relationship between RDW, bilirubin, and the clinical characteristics of patients with GC was analyzed.
A total of 144 patients with GC were enrolled. Patients with GC had significantly higher RDW than healthy controls, even after adjusting for hemoglobin, while total bilirubin (TBIL), direct bilirubin (DBIL) and indirect bilirubin (IBIL) were significantly decreased. Furthermore, RDW and bilirubin were significantly correlated with tumor stage, as well as carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9).
Our study indicated that RDW and bilirubin could be potential prognostic factors for patients of GC.
红细胞分布宽度（RDW）和胆红素已被证明是各类癌症的预后因素。然而，它们在胃癌（GC）患者中的预后价值仍 largely 未知。
为验证RDW和胆红素是否为GC患者的预后因素，我们进行了一项横断面研究，以分析RDW、胆红素与GC患者临床特征之间的关系。回顾性分析了2016年1月至2016年7月期间入住长征医院的所有新诊断且经病理证实的GC患者的病历。分析了RDW、胆红素与GC患者临床特征之间的关系。
共纳入144例GC患者。即使校正血红蛋白后，GC患者的RDW仍显著高于健康对照，而总胆红素（TBIL）、直接胆红素（DBIL）和间接胆红素（IBIL）则显著降低。此外，RDW和胆红素与肿瘤分期以及癌胚抗原（CEA）和糖类抗原19-9（CA19-9）显著相关。
我们的研究表明，RDW和胆红素可能是GC患者的潜在预后因素。
