术前红细胞分布宽度与血小板分布宽度联合对胃癌患者预后的意义。

Prognostic significance of the combination of preoperative red cell distribution width and platelet distribution width in patients with gastric cancer.

机构信息

Department of Surgery, Japanese Red Cross Tottori Hospital, 117 Shotoku-cho, Tottori, 680-8517, Japan.

Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.

出版信息

BMC Cancer. 2021 Dec 9;21(1):1317. doi: 10.1186/s12885-021-09043-5.

BACKGROUND

Platelet distribution width (PDW) and red cell distribution width (RDW) are readily obtainable data, and are reportedly useful as prognostic indicators in some cancers. However, their prognostic significance is unclear in gastric cancer (GC).

METHODS

We enrolled 445 patients with histopathological diagnoses of gastric adenocarcinoma who had undergone curative surgeries.

RESULTS

According to the optimal cut-off value of PDW and RDW by receiver operating characteristic (ROC) analysis, we divided patients into PDW (≥ 16.75%), PDW (< 16.75%), RDW (≥ 14.25%), and RDW (< 14.25%) subgroups. Overall survival (OS) was significantly worse in patients with PDW than in those with PDW (P = 0.0015), as was disease specific survival (P = 0.043). OS was also significantly worse in patients with RDW than in those with RDW (P < 0.0001), as was disease specific survival (P = 0.0002). Multivariate analysis for OS revealed that both PDW and RDW were independent prognostic indicators. Patients were then given PDW-RDW score by adding points for their different subgroups (1 point each for PDW and RDW; 0 points for PDW and RDW). OS significantly differed by PDW-RDW score (P < 0.0001), as did disease specific survival (P = 0.0005). In multivariate analysis for OS, PDW-RDW score was found to be an independent prognostic indicator.

CONCLUSIONS

The prognosis of GC patients can be precisely predictable by using both PDW and RDW.

背景

血小板分布宽度（PDW）和红细胞分布宽度（RDW）是易于获得的数据，据报道在某些癌症中可用作预后指标。然而，它们在胃癌（GC）中的预后意义尚不清楚。

方法

我们纳入了 445 名接受根治性手术的组织病理学诊断为胃腺癌的患者。

结果

根据 PDW 和 RDW 的 ROC 分析最佳截断值，我们将患者分为 PDW（≥16.75%）、PDW（<16.75%）、RDW（≥14.25%）和 RDW（<14.25%）亚组。PDW 患者的总生存期（OS）明显差于 PDW 患者（P=0.0015），疾病特异性生存期（P=0.043）也是如此。RDW 患者的 OS 明显差于 RDW 患者（P<0.0001），疾病特异性生存期（P=0.0002）也是如此。OS 的多变量分析显示，PDW 和 RDW 均为独立的预后指标。然后，通过为不同的亚组增加分数（PDW 和 RDW 各 1 分；PDW 和 RDW 各 0 分）来为患者分配 PDW-RDW 评分。OS 按 PDW-RDW 评分显著不同（P<0.0001），疾病特异性生存期也如此（P=0.0005）。OS 的多变量分析显示，PDW-RDW 评分是一个独立的预后指标。