Department of Neurobiology, Duke University, Durham, North Carolina, USA.
Duke Center for Neuroengineering, Duke University, Durham, North Carolina, USA.
Mov Disord. 2017 Jun;32(6):820-832. doi: 10.1002/mds.27033. Epub 2017 May 12.
Spinal cord stimulation has been used for the treatment of chronic pain for decades. In 2009, our laboratory proposed, based on studies in rodents, that electrical stimulation of the dorsal columns of the spinal cord could become an effective treatment for motor symptoms associated with Parkinson's disease (PD). Since our initial report in rodents and a more recent study in primates, several clinical studies have now described beneficial effects of dorsal column stimulation in parkinsonian patients. In primates, we have shown that dorsal column stimulation activates multiple structures along the somatosensory pathway and desynchronizes the pathological cortico-striatal oscillations responsible for the manifestation of PD symptoms. Based on recent evidence, we argue that neurological disorders such as PD can be broadly classified as diseases emerging from abnormal neuronal timing, leading to pathological brain states, and that the spinal cord could be used as a "channel" to transmit therapeutic electrical signals to disrupt these abnormalities. © 2017 International Parkinson and Movement Disorder Society.
脊髓刺激已被用于治疗慢性疼痛数十年。2009 年，我们的实验室根据对啮齿动物的研究提出，脊髓背柱的电刺激可能成为治疗帕金森病（PD）相关运动症状的有效方法。自我们在啮齿动物中的初步报告和最近在灵长类动物中的研究以来，现在已有几项临床研究描述了背柱刺激对帕金森病患者的有益作用。在灵长类动物中，我们已经表明，背柱刺激激活了沿着躯体感觉通路的多个结构，并使负责 PD 症状表现的病理性皮质纹状体振荡去同步。基于最近的证据，我们认为，诸如 PD 等神经疾病可以被广泛归类为源自异常神经元计时的疾病，导致病理性大脑状态，并且脊髓可以用作“通道”来传输治疗性电信号以破坏这些异常。©2017 国际帕金森病和运动障碍协会。
