Gu Christina, Liu Xiangping, Song Brian, Wang Wenliang, He Weilong, Wang Huiliang
Biomedical Engineering Cockrell School of Engineering, The University of Texas at Austin Austin Texas 78712 USA
Department of Neuroscience, The University of Texas at Austin Austin Texas 78712 USA.
Chem Sci. 2025 Jun 23. doi: 10.1039/d5sc02526e.
Mechanoluminescence has emerged as a promising tool for biomedical applications, particularly when paired with ultrasound to enable remote activation. These mechanoluminescent systems have shown potential by offering non-electrical, remote control over biological processes, particularly in fields of neuromodulation and bioimaging. Among these systems, organic mechanoluminescent nanoparticles have garnered attention for their biocompatibility, structural flexibility, light weight properties, and biodegradability, positioning them as ideal candidates for next-generation biomedical devices. This review summarizes recent progress on new designs, discoveries, and mechanisms in the research of organic mechanoluminescent materials, with a focus on their innovative applications in neuromodulation, bioimaging and theranostics; meanwhile also exploring their potential in optophysiology and other biomedical applications. By highlighting the advances of organic mechanoluminescent systems, this review underscores their transformative potential in enabling novel light-mediated bioapplications.
机械发光已成为生物医学应用中一种很有前景的工具，特别是与超声结合以实现远程激活时。这些机械发光系统通过对生物过程提供非电的远程控制，尤其在神经调节和生物成像领域，已显示出潜力。在这些系统中，有机机械发光纳米颗粒因其生物相容性、结构灵活性、轻质特性和可生物降解性而受到关注，使其成为下一代生物医学设备的理想候选者。本综述总结了有机机械发光材料研究中在新设计、发现和机制方面的最新进展，重点关注其在神经调节、生物成像和治疗诊断学中的创新应用；同时也探索它们在光生理学和其他生物医学应用中的潜力。通过强调有机机械发光系统的进展，本综述强调了它们在实现新型光介导生物应用方面的变革潜力。
