微小RNA-337可能是黑色素瘤中的关键负调控因子。
miR-337 can be a key negative regulator in melanoma.
作者信息
Xiao Wanan, Yao Enyang, Zheng Wei, Tian Feng, Tian Lijie
机构信息
a Department of Orthopedic Surgery , Shengjing Hospital of China Medical University , Shenyang , Liaoning , P.R. China.
出版信息
Cancer Biol Ther. 2017 Jun 3;18(6):392-399. doi: 10.1080/15384047.2017.1323581. Epub 2017 May 12.
Abstract
Incidence of melanoma is increasing annually worldwide. There remains a lack of suitable treatment methods which can significantly improve the 5-year survival rates of patients. It is established that micro RNAs (miRNAs) have important roles in the diagnosis and treatment of cancer. MiR-337 had been reported to regulate the development of variety of cancers, as a cancer suppressive factor. In our research we found that miR-337 had a lower expression in melanoma than adjacent tissues. The patients who had a lower miR-337 also got a worse survival. MiR-337 could target STAT3 to regulate the occurrence and development of melanoma. In summary, our findings suggest that the miR-337/STAT3 axis may serve as a potential target for the treatment of melanoma.
摘要
全球范围内，黑色素瘤的发病率逐年上升。目前仍然缺乏能够显著提高患者5年生存率的合适治疗方法。现已证实，微小RNA（miRNA）在癌症的诊断和治疗中发挥着重要作用。据报道，miR-337作为一种癌症抑制因子，可调节多种癌症的发展。在我们的研究中，我们发现miR-337在黑色素瘤中的表达低于相邻组织。miR-337水平较低的患者生存率也较差。miR-337可以靶向信号转导和转录激活因子3（STAT3）来调节黑色素瘤的发生和发展。总之，我们的研究结果表明，miR-337/STAT3轴可能成为黑色素瘤治疗的潜在靶点。
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