塞拉利昂埃博拉病毒病晚期疫情阶段的特征：临床、病毒学、免疫学及进化分析
Features of Ebola Virus Disease at the Late Outbreak Stage in Sierra Leone: Clinical, Virological, Immunological, and Evolutionary Analyses.
作者信息
Jiang Tao, Jiang Jia-Fu, Deng Yong-Qiang, Jiang Bao-Gui, Fan Hang, Han Jian-Feng, Hu Yi, Zhuang Dao-Min, Kargbo David, An Xiao-Ping, Mi Zhi-Qiang, Zhao Guang-Yu, Xin Wen-Wen, Tan Ya-Fang, He Jun, Gao Rong-Bao, Wang Hong, Chen Cao, Wang Feng, Li Chun-Xiao, Zhao Jian-Jun, Cui Yu-Jun, Bei Zhu-Chun, Zhang Ke, Shang Xue-Yi, Zhang Wen-Hui, Pei Guang-Qian, Wang Yun-Fei, Wang Wei, Shu Peng, Liu Wen-Li, Cheng Shi, Zhu Shun-Ya, Kanu Alex, Kargbo Brima, Gao Bo, Tong Yi-Gang, Fang Tong-Yu, Cao Wu-Chun
机构信息
State Key Laboratory of Pathogen and Biosecurity.
Ministry of Health and Sanitation, and.
出版信息
J Infect Dis. 2017 Apr 1;215(7):1107-1110. doi: 10.1093/infdis/jix061.
We performed Ebola virus disease diagnosis and viral load estimation for Ebola cases in Sierra Leone during the late stage of the 2014-2015 outbreak (January-March 2015) and analyzed antibody and cytokine levels and the viral genome sequences. Ebola virus disease was confirmed in 86 of 1001 (9.7%) patients, with an overall case fatality rate of 46.8%. Fatal cases exhibited significantly higher levels of viral loads, cytokines, and chemokines at late stages of infection versus early stage compared with survivors. The viruses converged in a new clade within sublineage 3.2.4, which had a significantly lower case fatality rate.
在2014 - 2015年疫情后期（2015年1月至3月），我们对塞拉利昂的埃博拉病例进行了埃博拉病毒病诊断和病毒载量估计，并分析了抗体、细胞因子水平及病毒基因组序列。1001名患者中有86例（9.7%）确诊为埃博拉病毒病，总体病死率为46.8%。与幸存者相比，死亡病例在感染后期的病毒载量、细胞因子和趋化因子水平显著高于早期。这些病毒聚集在3.2.4亚谱系内的一个新分支中，该分支的病死率显著较低。
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