Rauf Abdur, Uddin Ghias, Patel Seema, Khan Ajmal, Halim Sobia Ahsan, Bawazeer Saud, Ahmad Khalid, Muhammad Naveed, Mubarak Mohammad S
Department of Chemistry, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan.
Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan.
Biomed Pharmacother. 2017 Jul;91:714-730. doi: 10.1016/j.biopha.2017.05.012. Epub 2017 May 9.
The genus Diospyros from family Ebenaceae has versatile uses including edible fruits, valuable timber, and ornamental uses. The plant parts of numerous species have been in use as remedies in various folk healing practices, which include therapy for hemorrhage, incontinence, insomnia, hiccough, diarrhea etc. Phytochemical constituents such as terpenoids, ursanes, lupanes, polyphenols, tannins, hydrocarbons, and lipids, benzopyrones, naphthoquinones, oleananes, and taraxeranes have been isolated from different species of this genus. The biological activities of these plants such as antioxidant, anti-inflammatory, analgesic, antipyretic, anti-diabetic, antibacterial, anthelmintic, antihypertensive, cosmeceutical, enzyme-inhibitory etc. have been validated by means of an in vitro, in vivo, and clinical tests. As a rich reserve of pharmacologically important components, this genus can accelerate the pace of drug discovery. Accordingly, the aim of the present review is to survey and summarize the recent literature pertaining to the medicinal and pharmacological uses of Diospyros, and to select experimental evidence on the pharmacological properties of this genus. In addition, the review also aims at identifying areas that need development to make use of this genus, especially its fruit and phytochemicals as means for economic development and for drug discovery.
柿科柿属植物具有多种用途，包括可食用的果实、珍贵的木材以及观赏价值。许多柿属植物的各个部位在各种民间疗法中都被用作药物，这些疗法包括治疗出血、失禁、失眠、打嗝、腹泻等。从该属的不同物种中已分离出多种植物化学成分，如萜类化合物、乌苏烷、羽扇豆烷、多酚、单宁、碳氢化合物、脂质、苯并吡喃、萘醌、齐墩果烷和蒲公英赛烷。这些植物的生物活性，如抗氧化、抗炎、镇痛、解热、抗糖尿病、抗菌、驱虫、降压、药妆、酶抑制等，已通过体外、体内和临床试验得到验证。作为药理学重要成分的丰富来源，该属可以加快药物发现的步伐。因此，本综述的目的是调查和总结最近有关柿属药用和药理用途的文献，并选取该属药理特性的实验证据。此外，该综述还旨在确定需要开发利用该属的领域，特别是其果实和植物化学成分，作为经济发展和药物发现的手段。
