Fishberg Department of Neuroscience and Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Fishberg Department of Neuroscience and Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pharmacol Biochem Behav. 2017 Nov;162:79-86. doi: 10.1016/j.pbb.2017.05.003. Epub 2017 May 10.
Inter-male aggression is an essential component of social behavior in organisms from insects to humans. However, when expressed inappropriately, aggression poses significant threats to the mental and physical health of both the aggressor and the target. Inappropriate aggression is a common feature of numerous neuropsychiatric disorders in humans and has been hypothesized to result from the atypical activation of reward circuitry in response to social targets. The lateral habenula (LHb) has recently been identified as a major node of the classical reward circuitry and inhibits the release of dopamine from the midbrain to signal negative valence. Here, we discuss the evidence linking LHb function to aggression and its valence, arguing that strong LHb outputs to the ventral tegmental area (VTA) and the dorsal raphe nucleus (DRN) are likely to play roles in aggression and its rewarding components. Future studies should aim to elucidate how various inputs and outputs of the LHb shape motivation and reward in the context of aggression.
雄性间攻击是从昆虫到人类等生物社会行为的一个重要组成部分。然而，当表现不当时，攻击会对攻击者和目标的身心健康造成重大威胁。不适当的攻击是人类许多神经精神疾病的共同特征，据推测是由于对社会目标的反应中奖励回路的异常激活所致。外侧缰核（LHb）最近被确定为经典奖励回路的主要节点，并抑制从中脑释放多巴胺以发出负面情绪信号。在这里，我们讨论了将 LHb 功能与攻击性及其效价联系起来的证据，认为强烈的 LHb 输出到腹侧被盖区（VTA）和中缝背核（DRN）可能在攻击性及其奖励成分中发挥作用。未来的研究应旨在阐明 LHb 的各种输入和输出如何在攻击的背景下塑造动机和奖励。
