Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Front Med. 2017 Sep;11(3):359-364. doi: 10.1007/s11684-017-0528-5. Epub 2017 May 13.
Thyroid-associated orbitopathy (TAO) is an inflammatory autoimmune disorder. The most serious complication of TAO is dysthyroid optic neuropathy (DON), which can lead to permanent vision loss because of volume expansion in the orbital apex. Orbital radiation therapy (ORT) is an anti-inflammatory treatment used in the treatment of active TAO. Clinical studies support radiotherapy as having a modest effect on DON, and early radiotherapy may protect against disease progression to DON. Current studies suggest that radiotherapy is generally safe. However, risks still exist in some cases. The possible effects of radiotherapy on TAO, especially complicated with DON, are reviewed. The effects of radiotherapy on DON are not completely known, and evidence from standardized, prospective, and multicenter clinical trials is still lacking.
甲状腺相关眼病（TAO）是一种炎症性自身免疫性疾病。TAO 最严重的并发症是甲状腺机能亢进性视神经病变（DON），由于眶尖容积增大，可导致永久性视力丧失。眼眶放射治疗（ORT）是一种用于治疗活动性 TAO 的抗炎治疗方法。临床研究支持放射治疗对 DON 有一定疗效，早期放射治疗可能有助于防止疾病进展为 DON。目前的研究表明，放射治疗通常是安全的。然而，在某些情况下仍然存在风险。本文回顾了放射治疗对 TAO 的可能影响，特别是对伴有 DON 的 TAO 的影响。放射治疗对 DON 的影响尚不完全清楚，仍然缺乏来自标准化、前瞻性和多中心临床试验的证据。
