Li Jia, An Changlong, Kang Lei, Mitch William E, Wang Yanlin
Selzman Institute for Kidney Health and Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, TX; and Center for Translational Research on Inflammatory Diseases (CTRID) and Renal Section, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX.
Selzman Institute for Kidney Health and Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, TX; and Center for Translational Research on Inflammatory Diseases (CTRID) and Renal Section, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX.
Adv Chronic Kidney Dis. 2017 May;24(3):150-153. doi: 10.1053/j.ackd.2017.03.005.
CKD is a global public health problem. Renal fibrosis is a final common pathway leading to progressive loss of function in CKD. The degree of renal fibrosis predicts the prognosis of CKD. Recent studies have shown that bone marrow-derived fibroblasts contribute significantly to the development of renal fibrosis, which may yield novel therapeutic strategy for fibrotic kidney disease. Therefore, it is imperative to accurately assess the degree of renal fibrosis noninvasively to identify those patients who can benefit from antifibrotic therapy. In this review, we summarize recent advances in the assessment of renal fibrosis by magnetic resonance imaging.
慢性肾脏病是一个全球性的公共卫生问题。肾纤维化是导致慢性肾脏病功能进行性丧失的最终共同途径。肾纤维化程度可预测慢性肾脏病的预后。最近的研究表明，骨髓来源的成纤维细胞对肾纤维化的发展有显著贡献，这可能为纤维化肾病带来新的治疗策略。因此，必须通过非侵入性方法准确评估肾纤维化程度，以确定那些能从抗纤维化治疗中获益的患者。在本综述中，我们总结了磁共振成像评估肾纤维化的最新进展。
