Dong Xin, Gou Wenli, Li Chunfang, Wu Min, Han Zhen, Li Xuelan, Chen Qi
Department of Obstetrics & Gynaecology, First Affiliated Hospital of Xi'an Jiaotong University, China.
Department of Obstetrics & Gynaecology, First Affiliated Hospital of Xi'an Jiaotong University, China.
Pregnancy Hypertens. 2017 Apr;8:60-64. doi: 10.1016/j.preghy.2017.03.005. Epub 2017 Mar 20.
Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality globally and proteinuria can be one of the cardinal features of this disease. However, studies about the association of the amount of proteinuria and the severity of preeclampsia, and perinatal outcomes are limited. Data on 239 women with preeclampsia were retrospectively collected from a university teaching hospital from September 2011 to June 2013 and analysed. Data included all clinical parameters and proteinuria in a 24h urine collection. In cases of severe preeclampsia, significantly fewer patients had proteinuria levels <0.3g/L in comparison to any of the other groups with proteinuria >0.3g/L, but there was no difference in cases of severe preeclampsia when proteinuria levels were >0.3g/L. Furthermore, when proteinuria levels were >0.3g/L, the frequency of severe preeclampsia in each group was significantly higher than the frequency of mild pre-eclampsia cases. Time of onset was significantly earlier in patients with proteinuria >3g/L in a 24h urine collection, but time between the onset of preeclampsia and delivery was not correlated with the amount of proteinuria. The birth weight was significantly lower in patients with proteinuria >3g/L. The incidence of fetal growth restriction or stillbirth was significantly higher in patients with proteinuria >5g/L. Our data demonstrate that the amount of proteinuria is not associated with the severe of preeclampsia, once proteinuria is detected, but is related to the severity of preeclampsia. The adverse fetal outcomes appear to be the function of prematurity rather than proteinuria itself.
子痫前期是全球孕产妇和围产儿发病及死亡的主要原因之一，蛋白尿可能是该疾病的主要特征之一。然而，关于蛋白尿的量与子痫前期严重程度及围产儿结局之间关联的研究有限。2011年9月至2013年6月，我们从一所大学教学医院回顾性收集并分析了239例子痫前期患者的数据。数据包括所有临床参数以及24小时尿蛋白定量。在重度子痫前期病例中，与蛋白尿水平>0.3g/L的其他任何组相比，蛋白尿水平<0.3g/L的患者明显更少，但当蛋白尿水平>0.3g/L时，重度子痫前期病例之间没有差异。此外，当蛋白尿水平>0.3g/L时，每组重度子痫前期的发生率明显高于轻度子痫前期病例的发生率。24小时尿蛋白定量>3g/L的患者发病时间明显更早，但子痫前期发病至分娩的时间与蛋白尿的量无关。蛋白尿>3g/L的患者出生体重明显更低。蛋白尿>5g/L的患者胎儿生长受限或死产的发生率明显更高。我们的数据表明，一旦检测到蛋白尿，其含量与子痫前期的严重程度无关，但与子痫前期的严重程度相关。不良胎儿结局似乎是早产的结果，而非蛋白尿本身所致。
