Clinic for Animal Reproduction, Faculty of Veterinary Medicine, Freie Universität Berlin Königsweg 65, 14163 Berlin, Germany.
Clinic for Animal Reproduction, Faculty of Veterinary Medicine, Freie Universität Berlin Königsweg 65, 14163 Berlin, Germany.
J Dairy Sci. 2017 Jul;100(7):5462-5467. doi: 10.3168/jds.2016-12237. Epub 2017 May 10.
The objectives of this study were to describe the associations between hypoglycemia and the onset of hyperketonemia (HYK) within the first 6 wk of lactation, to evaluate the effects of body condition score at calving on glucose concentration, and to study the effects of hypoglycemia on milk production. A total of 621 dairy cows from 6 commercial dairy farms in Germany were enrolled between 1 and 4 d in milk (DIM). Cows were tested twice weekly using an electronic handheld meter for glucose and β-hydroxybutyrate (BHB), respectively, for a period of 42 d. Hypoglycemia was defined as glucose concentration ≤2.2 mmol/L. Hyperketonemia was defined as a BHB concentration ≥1.2 mmol/L. The onset of HYK was described as early onset (first HYK event within the first 2 wk postpartum) and late onset (first HYK event in wk 3 to 6 postpartum). The effect of ketosis status on blood glucose within 42 DIM was evaluated using a generalized linear mixed model. No effect was observed of HYK on glucose concentration in primiparous cows. Multiparous cows with early-onset HYK had a lower glucose concentration (-0.21 mmol/L) compared with nonketotic cows. Overall, primiparous cows had a lower prevalence and incidence of hypoglycemia than multiparous cows. Hypoglycemia in multiparous cows was associated with higher first test-day milk production and 100 DIM milk production. In conclusion, hypoglycemia mainly occurred in multiparous cows with early-onset HYK, whereas primiparous cows were at a lower risk for hypoglycemia.
本研究的目的是描述哺乳期前 6 周内低血糖与高酮血症（HYK）发作之间的关系，评估产犊时体况评分对血糖浓度的影响，并研究低血糖对产奶量的影响。共有 621 头来自德国 6 个商业奶牛场的奶牛在产奶后 1 至 4 天（DIM）期间被纳入研究。奶牛每周接受两次电子手持式血糖仪检测，分别检测血糖和β-羟丁酸（BHB），持续 42 天。低血糖定义为血糖浓度≤2.2mmol/L。高酮血症定义为 BHB 浓度≥1.2mmol/L。HYK 的发作被描述为早期发作（产后前 2 周内首次发生 HYK 事件）和晚期发作（产后第 3 周至第 6 周首次发生 HYK 事件）。使用广义线性混合模型评估酮症状态对 42 DIM 内血糖的影响。初产奶牛的 HYK 对血糖浓度没有影响。与非酮病奶牛相比，早发性 HYK 的经产奶牛血糖浓度较低（-0.21mmol/L）。总体而言，初产奶牛的低血糖患病率和发病率低于经产奶牛。经产奶牛的低血糖与首次测试日产奶量和 100 DIM 产奶量较高有关。总之，低血糖主要发生在早发性 HYK 的经产奶牛中，而初产奶牛发生低血糖的风险较低。
