由胶孢炭疽菌引起的角膜炎的临床和真菌学特征：病例报告及文献复习。

Clinical and mycological characteristics of keratitis caused by Colletotrichum gloeosporioides: A case report and review of literature.

机构信息

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Department of Ocular Trauma and Emergency, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

J Infect Dev Ctries. 2021 Mar 7;15(2):301-305. doi: 10.3855/jidc.14492.

DOI:10.3855/jidc.14492

PMID:33690215

Abstract

INTRODUCTION

Colletotrichum species are well-known plant pathogens, which have been increasingly reported as the cause of keratitis or subcutaneous lesions in humans. In this study we reported a rare case of fungal keratitis from Iran and reviewed the literature.

CASE PRESENTATION

A 69-year-old man whose right eye was injured by herbal material was examined by slit-lamp biomicroscopy and mycology investigation of corneal scrapings was done. The grown filamentous fungal was identified as Colletotrichum gloeosporioides based on morphological characteristics and DNA sequence of the internal transcribed spacer region. The isolated strain was sensitive to amphotericin B, caspofungin, anidolafungin, micafungin, voriconazole, and relatively resistant to fluconazole, and itraconazole. Patient was successfully treated with voriconazole.

CONCLUSIONS

This report highlights that the early and accurate identification and therapy can helpful to management keratitis caused by C. gloeosporioides.

摘要

简介

炭疽菌属是众所周知的植物病原体，越来越多的报道称其是人类角膜炎或皮下病变的病因。在本研究中，我们报告了伊朗一例罕见的真菌性角膜炎病例，并复习了相关文献。

病例介绍

一位 69 岁的男性，右眼被草药材料所伤，我们对其进行了裂隙灯生物显微镜检查，并对角膜刮片进行了真菌学检查。根据形态学特征和内部转录间隔区的 DNA 序列，生长出的丝状真菌被鉴定为胶孢炭疽菌。分离株对两性霉素 B、卡泊芬净、阿尼多霉素、米卡芬净、伏立康唑敏感，对氟康唑和伊曲康唑相对耐药。患者经伏立康唑治疗后痊愈。