Sokołowska Lilianna, Bylka Wiesława
Katedra i Zakład Farmakognozji, Uniwersytet Medyczny im. Karola Marcinkowskiego, Poznań.
Wiad Lek. 2015;68(3 pt 2):358-362.
Recently appeared medicinal preparations containing an extract of Bacopa monnieri. B. monnieri has been used in the Ayurvedic system of medicine for centuries, especially to enhance cognitive functions. Active compounds in this plant include numerous saponins type dammarane, mainly bacoside A and B, alkaloids and sterols. The pharmacological research of the extract of Bacopa monnieri support traditional uses of this plant. The results of so far clinical studies of the extract from B. monnieri, indicate to beneficial effect on memory, learning and concentration in adults, children and to improve in anxiety and depression after prolonged administration, although further clinical studies are needed to confirm medical indications. It has been found to be well tolerated. The present review summarizes current knowledge of mechanisms of actions also presents of dietary supplements with B. monnieri.
最近出现了含有积雪草提取物的药用制剂。几个世纪以来,积雪草一直在阿育吠陀医学体系中使用,尤其用于增强认知功能。这种植物中的活性化合物包括多种达玛烷型皂苷,主要是积雪草苷A和B、生物碱和甾醇。积雪草提取物的药理学研究支持了这种植物的传统用途。迄今为止,对积雪草提取物的临床研究结果表明,它对成年人、儿童的记忆、学习和注意力有有益影响,长期服用后还能改善焦虑和抑郁,不过还需要进一步的临床研究来证实其医学适应症。已发现它耐受性良好。本综述总结了当前关于其作用机制的知识,还介绍了含有积雪草的膳食补充剂。