Zieneldien Tarek, Kim Janice, Cao Chuanhai
Department of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33620, USA.
Geriatrics (Basel). 2022 Feb 26;7(2):24. doi: 10.3390/geriatrics7020024.
Alzheimer's disease (AD) is an age-related, progressive neurodegenerative disorder characterized by impaired cognition, memory loss, and altered personality. Many of the available pharmaceutical treatments do not alter the onset of disease progression. Recently, alternatives to developed drug candidates have been explored including medicinal plants and herbal treatments for the treatment of AD. This article examines the role of herbal plant extracts and the neuroprotective effects as alternative modes of intervention for AD progression. These extracts contain key metabolites that culminate alterations in AD progression. The traditional plant extracts explored in this article induce a variety of beneficial properties, including antioxidants, anti-inflammatory, and enhanced cognition, while also inducing activity on AD drug targets such as Aβ degradation. While these neuroprotective aspects for AD are relatively recent, there is great potential in the drug discovery aspect of these plant extracts for future use in AD treatment.
阿尔茨海默病（AD）是一种与年龄相关的进行性神经退行性疾病，其特征为认知受损、记忆力丧失和性格改变。许多现有的药物治疗并不能改变疾病进展的起始。最近，人们探索了已开发候选药物的替代方案，包括用于治疗AD的药用植物和草药疗法。本文探讨了草药植物提取物的作用以及作为AD进展替代干预模式的神经保护作用。这些提取物含有关键代谢物，最终导致AD进展的改变。本文探讨的传统植物提取物具有多种有益特性，包括抗氧化、抗炎和增强认知，同时还对AD药物靶点如β-淀粉样蛋白（Aβ）降解产生作用。虽然这些AD的神经保护方面相对较新，但这些植物提取物在药物发现方面具有巨大潜力，可用于未来的AD治疗。
