Khattab Sahar S, El-Saied Amany M, Mohammed Rehab A, Mohamed Eman E
Department of Clinical Pathology, Faculty of Medecine for Girls, Al-Azhar University, Cairo, Egypt.
Department of Internal Medicine, Faculty of Medecine for Girls, Al-Azhar University, Cairo, Egypt.
Egypt J Immunol. 2016 Jun;23(2):87-95.
Rheumatoid arthritis (RA) is an autoimmune disease characterized by disturbed immune regulation, inducing a progressive cartilage and bone destruction. Despite enrichment of T regulatory cell (T-regs) in synovial fluid, conflicting results are reported concerning T-regs in peripheral blood (PB) of RA patients. To determine possible correlation between the frequency of PB CD4+ CD25+CD127low (T-regs) with RA disease activity. Forty females with RA, classified according to the Disease Activity Score 28 (DAS-28), as highly active, mild-moderate or low disease activity; and 20 age and sex matched healthy controls, were enrolled to study CD4+ CD25+ CD127low T- regs in PB by flow cytometry. Active RA patients had lower frequency of the CD4+ CD25+ CD127low T- regs compared to those with mild-moderate or low disease activity (P <0.001). The frequencies of the T- regs showed negative correlation with the DAS-28 (P<0.01). In conclusion, CD4+ CD25+ CD127low T-regs is significantly lower in highly active RA patients compared to patients with lower activity or controls.
类风湿关节炎（RA）是一种自身免疫性疾病，其特征是免疫调节紊乱，导致软骨和骨的进行性破坏。尽管滑膜液中调节性T细胞（T-regs）增多，但关于RA患者外周血（PB）中T-regs的报道结果相互矛盾。为了确定外周血CD4 + CD25 + CD127low（T-regs）频率与RA疾病活动之间的可能相关性。根据疾病活动评分28（DAS-28）将40名患有RA的女性分为高活动度、轻度-中度或低疾病活动度；并纳入20名年龄和性别匹配的健康对照，通过流式细胞术研究外周血中CD4 + CD25 + CD127low T-regs。与轻度-中度或低疾病活动度的患者相比，活动性RA患者的CD4 + CD25 + CD127low T-regs频率较低（P <0.001）。T-regs频率与DAS-28呈负相关（P <0.01）。总之，与低活动度患者或对照组相比，高活动度RA患者的CD4 + CD25 + CD127low T-regs明显更低。
