ELBadawy Nissreen E, El-Anwar Mohammad W
Department of Medical Microbiology & Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Department of Otorhinolaryngology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Egypt J Immunol. 2016 Jan;23(1):45-56.
Many cases of AR can be miss-diagnosed due to deficiency in the conventional laboratory tools. Detection of local Ig E immune response and allergy associated genes may aid in diagnosis of these cases. The local immune response and the allergy associated genes of these suspected cases must be evaluated as they may help in their characterization. This study was conducted on 129 patients with chronic rhinitis to determine the frequency of LAR, and analyze the association of IgE receptor (FcεR1β) gene polymorphism with LAR. All participants were subjected to clinical questionnaire, skin prick test, specific IgE measurement in serum and nasal secretions and analysis of FcεR1β gene polymorphism. LAR constituted 24.8 % of total rhinitis cases and 44.4% of non-allergic cases. Cockroach was the main sensitizing agent in local allergic rhinitis in comparison with allergic cases (OR =0.11; 95% CI= 0.04-0.34; P<0.001). In LAR, nasal specific Ig E was significantly lower than that in AR patients (P < 0.001). FcεR1β genotype TT was more frequently expressed in LAR and AR than non-allergic rhinitis (NAR) (P< 0.001). It is concluded that LAR is an emerging allergic condition that could be diagnosed by nasal specific IgE, and that FcεR1β polymorphism is one of the genetic factors associated with AR and LAR.
由于传统实验室检测手段的不足，许多变应性鼻炎（AR）病例可能被误诊。检测局部IgE免疫反应和过敏相关基因可能有助于这些病例的诊断。必须评估这些疑似病例的局部免疫反应和过敏相关基因，因为它们可能有助于对病例进行特征描述。本研究对129例慢性鼻炎患者进行，以确定迟发性变应性鼻炎（LAR）的发生率，并分析IgE受体（FcεR1β）基因多态性与LAR的相关性。所有参与者均接受临床问卷调查、皮肤点刺试验、血清和鼻分泌物中特异性IgE检测以及FcεR1β基因多态性分析。LAR占鼻炎病例总数的24.8%，占非变应性鼻炎病例的44.4%。与变应性鼻炎病例相比，蟑螂是局部变应性鼻炎的主要致敏原（比值比=0.11；95%可信区间=0.04-0.34；P<0.001）。在LAR中，鼻特异性IgE显著低于AR患者（P<0.001）。FcεRβ基因型TT在LAR和AR中的表达频率高于非变应性鼻炎（NAR）（P<0.001）。得出的结论是，LAR是一种新出现的变应性疾病，可通过鼻特异性IgE进行诊断，且FcεR1β多态性是与AR和LAR相关的遗传因素之一。
