Krajewska-Wojtys Anna, Jarzab Jerzy, Zawadzińska Kamila, Pyrkosz Katarzyna, Bozek Andrzej
Clinical Department of Internal Diseases, Dermatology, and Allergology, Medical University of Silesia, Zabrze, Poland.
Int Arch Allergy Immunol. 2017;173(3):165-170. doi: 10.1159/000478656. Epub 2017 Aug 9.
Local allergic rhinitis (LAR) remains an underdiagnosed condition characterized by the local production of IgE antibodies during the natural exposure to aeroallergens. The prevalence of LAR in adult patients with a previous diagnosis of non-AR was assessed.
Eighty-four patients with perennial nasal allergy symptoms but a negative skin prick test and specific IgE antibodies against common inhalant allergens were included in the study. Nasal provocation tests were performed with the inhalant allergens Dermatophagoides pteronyssinus, Alternaria, and cat allergen, followed by the detection of nasal-specific IgE antibodies in the lavage during the challenge.
LAR was confirmed in 21 (25%) study patients. In the remaining 63 (75%) patients, non-AR was diagnosed. In addition, LAR was found following exposure to D. pteronyssinus in 19 (22.6%) patients, Alternaria in 3 (3.6%) patients, and the cat allergen in 1 (1.2%) patient. In 2 patients, concomitant allergies to D. pteronyssinus and Alternaria were observed.
LAR can be a form of chronic perennial rhinitis that has previously been considered to be non-AR.
局部变应性鼻炎（LAR）仍然是一种诊断不足的疾病，其特征是在自然接触气传变应原期间局部产生IgE抗体。本研究评估了既往诊断为非变应性鼻炎（non-AR）的成年患者中LAR的患病率。
本研究纳入了84例有常年性鼻过敏症状但皮肤点刺试验阴性且针对常见吸入性变应原的特异性IgE抗体阴性的患者。用吸入性变应原屋尘螨、链格孢属和猫变应原进行鼻激发试验，随后在激发过程中检测灌洗液中的鼻特异性IgE抗体。
21例（25%）研究患者确诊为LAR。其余63例（75%）患者诊断为非AR。此外，19例（22.6%）患者在接触屋尘螨后出现LAR，3例（3.6%）患者在接触链格孢属后出现LAR，1例（1.2%）患者在接触猫变应原后出现LAR。2例患者同时对屋尘螨和链格孢属过敏。
LAR可能是一种慢性常年性鼻炎，以前被认为是非AR。
