Berghi Ovidiu, Dumitru Mihai, Cergan Romica, Musat Gabriela, Serboiu Crenguta, Vrinceanu Daniela
Allergology Department, Colentina Clinical Hospital, 020125 Bucharest, Romania.
ENT Department, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Life (Basel). 2024 Jul 31;14(8):965. doi: 10.3390/life14080965.
Local allergic rhinitis (LAR) represents a medical provocation for allergists and otorhinolaryngologists. LAR is considered to be a subtype of allergic rhinitis (AR) that affects a great percentage of patients who were, for decades, diagnosed as having chronic non-allergic rhinitis. The clinical picture is represented by rhinorrhea, sneezing, and nasal itching correlated with specific pollen season or dust, mold, or pet interior exposure. Usual assessment of AR (skin prick testing and serum IgE assessment) produces negative results. Specialized centers in allergology and ENT around the globe use a nasal allergen challenge, assessment of local IgE, basophil activation test (BAT), and nasal cytology in the diagnostic approach to the disease, taking into account their current limitations. The impact of LAR on quality-of-life indicators is the same as in AR. Treatment for LAR is similar to that for AR and is the same as for AR: allergen exposure avoidance, drug therapy, and allergen immunotherapy. This scoping review gathers the current up-to-date open access evidence available on PubMed on the subject of LAR.
局部过敏性鼻炎（LAR）对过敏症专科医生和耳鼻喉科医生来说是一个医学难题。LAR被认为是过敏性鼻炎（AR）的一种亚型，它影响着很大一部分患者，这些患者几十年来一直被诊断为患有慢性非过敏性鼻炎。临床表现为与特定花粉季节或灰尘、霉菌或宠物室内接触相关的流涕、打喷嚏和鼻痒。AR的常规评估（皮肤点刺试验和血清IgE评估）结果为阴性。全球各地的过敏症和耳鼻喉科专业中心在该疾病的诊断方法中采用鼻过敏原激发试验、局部IgE评估、嗜碱性粒细胞活化试验（BAT）和鼻细胞学检查，同时考虑到它们目前的局限性。LAR对生活质量指标的影响与AR相同。LAR的治疗与AR相似，与AR相同：避免接触过敏原、药物治疗和过敏原免疫治疗。这篇综述收集了目前在PubMed上可获取的关于LAR主题的最新开放获取证据。
