Nikolaĭ S L
Farmakol Toksikol. 1988 Sep-Oct;51(5):65-8.
It was shown that in the rats exposed to hyperbaric oxygenation, as compared to the animals being under normal atmospheric conditions, nitroglycerin did not increase the level of free radicals (FR) in the myocardium and liver and significantly decreased the amplitude of nitrosyl complexes of iron in the liver. The obsidan-induced changes of FR and final products of lipid peroxidation in the myocardium were prevented. Isoptine was found to increase the contents of FR and final products of lipid peroxidation in the animal liver.
结果表明，与处于正常大气条件下的动物相比，暴露于高压氧环境的大鼠，其心肌和肝脏中的自由基（FR）水平在使用硝酸甘油后并未升高，且肝脏中铁亚硝酰复合物的幅度显著降低。黑曜石诱导的心肌中FR和脂质过氧化终产物的变化得到了预防。发现异搏定可增加动物肝脏中FR和脂质过氧化终产物的含量。
