Horváth Örs Péter, Bognár Laura, Papp András, Vereczkei András
Klinikai Központ, Sebészeti Klinika, Pécsi Tudományegyetem Pécs, Ifjúság útja 13., 7624.
Sebészeti Oktató és Kutató Intézet, Pécsi Tudományegyetem Pécs.
Orv Hetil. 2017 May;158(20):763-769. doi: 10.1556/650.2017.30759.
Gastroesophageal reflux disease affects more than 10% of the adult population. Most patients can be effectively treated with lifestyle changes and adequate acid-reducing therapy. However, about 10% of the patients remain symptomatic despite treatment and severe complications may develop. Interestingly, some of these complications seem to be a sort of defensive mechanism that may either alleviate the patient's symptoms or prevent developing further complications. In Barrett's esophagus, which can be unambigously considered as a complication of gastroesophageal reflux disease, reflux symptoms ruining the quality of life may significantly improve, since the metaplastic Barrett epithelium is much more resistent to gastric acid, than the normal epithelial lining of the esophagus. Furthermore, the motility disorders (hypertensive lower esophageal sphincter, achalasia, cricopharyngeal achalasia) and structural changes (Schatzki's ring, esophageal stricture, subglottic trachea stenosis), which develop as a complication of reflux may help to prevent aspiration that can cause new complaints and may lead to further complications. Orv Hetil. 2017; 158(20): 763-769.
胃食管反流病影响着超过10%的成年人口。大多数患者可通过生活方式改变和适当的抑酸治疗得到有效治疗。然而，约10%的患者尽管接受了治疗仍有症状，且可能会出现严重并发症。有趣的是，其中一些并发症似乎是一种防御机制，可能会缓解患者症状或防止进一步并发症的发生。在巴雷特食管中，这可明确被视为胃食管反流病的一种并发症，破坏生活质量的反流症状可能会显著改善，因为化生的巴雷特上皮比食管正常上皮衬里对胃酸更具抵抗力。此外，作为反流并发症出现的运动障碍（食管下括约肌高压、贲门失弛缓症、环咽肌失弛缓症）和结构改变（沙茨基环、食管狭窄、声门下气管狭窄）可能有助于预防可引起新症状并可能导致进一步并发症的误吸。《匈牙利医学周报》。2017年；158(20): 763 - 769。
