生酮饮食在加纳一名难治性癫痫患儿身上的首次应用。
First Application of Ketogenic Diet on a Child With Intractable Epilepsy in Ghana.
作者信息
Cao Dezhi, Badoe Eben, Zhu Yanwei, Zhao Xia, Hu Yan, Liao Jianxiang
机构信息
Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Department of Child Health, College of Medicine and Child Health, University of Ghana.
出版信息
Child Neurol Open. 2015 Sep 21;2(3):2329048X15604593. doi: 10.1177/2329048X15604593. eCollection 2015 Jul-Sep.
The prevalence of epilepsy in sub-Saharan Africa is higher than in other parts of the world, but it is short of the effective measure on treating intractable epilepsy. Epilepsy surgery is not easy to be performed due to the high cost and demand of operational skills. The authors planned to perform ketogenic diet therapy for the children with intractable epilepsy in Ghana with regard to its low cost and simple procedure. The candidate is a 10-month-old girl with epilepsy with unknown etiology. Her seizures couldn't be controlled by more than 3 antiepileptic drugs. Her development delayed severely due to frequent seizures. The authors successfully applied ketogenic diet for her. Her seizures were completely controlled after 2 weeks' therapy. Her mental condition was improved after that. The authors get much experience from this case for further developing ketogenic diet in Africa. This is the first report that ketogenic diet was applied to control intractable epilepsy in West Africa.
撒哈拉以南非洲地区癫痫的患病率高于世界其他地区，但在治疗难治性癫痫方面缺乏有效措施。由于成本高昂且对手术技能要求较高，癫痫手术不易开展。鉴于生酮饮食疗法成本低且操作简单，作者计划对加纳患有难治性癫痫的儿童实施该疗法。候选对象是一名10个月大病因不明的癫痫女童。超过3种抗癫痫药物都无法控制她的癫痫发作。由于频繁发作，她的发育严重迟缓。作者成功地为她应用了生酮饮食疗法。经过2周的治疗，她的癫痫发作完全得到控制。此后她的精神状况有所改善。作者从这个病例中获得了很多经验，以便在非洲进一步推广生酮饮食疗法。这是第一份关于在西非应用生酮饮食疗法控制难治性癫痫的报告。
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