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与感染相关的脑病和轴索性神经病:对静脉注射免疫球蛋白治疗的反应

Encephalopathy and Axonal Neuropathy Associated With Infection: Response to Intravenous Immunoglobulin Therapy.

作者信息

Saker Ali, Athman Stephanie, Aldosari Mohammed, Frayha Husn

机构信息

Damascus University, Faculty Of Medicine, Damascus, Syria.

Nationwide Children's Hospital, Columbus, OH, USA.

出版信息

Child Neurol Open. 2016 Apr 4;3:2329048X16632140. doi: 10.1177/2329048X16632140. eCollection 2016 Jan-Dec.

Abstract

infection frequently presents as a self-limited process, however, severe cases and even fatalities have been reported. The authors present a case of infection associated with both encephalopathy and peripheral neuropathy that responded to intravenous immunoglobulin therapy. To our knowledge, this is the first documented case of related to encephalitis and peripheral axonal neuropathy. To date, there is insufficient data on the effect of intravenous immunoglobulin on the course of mycoplasma-associated central nervous system/peripheral nervous system disease. While intravenous immunoglobulin has aided in a variety of autoimmune-mediated disorders, its efficacy in mycoplasma-mediated encephalitis treatment remains unclear. In this patient case, reversal of both central and peripheral nervous system symptoms after treatment with intravenous immunoglobulin suggested a possible therapeutic benefit.

摘要

感染通常表现为一个自限性过程,然而,也有严重病例甚至死亡的报道。作者报告了一例与脑病和周围神经病变相关的感染病例,该病例对静脉注射免疫球蛋白治疗有反应。据我们所知,这是首例与脑炎和周围轴索性神经病变相关的病例记录。迄今为止,关于静脉注射免疫球蛋白对支原体相关的中枢神经系统/周围神经系统疾病病程的影响,数据尚不充分。虽然静脉注射免疫球蛋白有助于治疗多种自身免疫介导的疾病,但其在支原体介导的脑炎治疗中的疗效仍不明确。在该患者病例中,静脉注射免疫球蛋白治疗后中枢和周围神经系统症状均得到缓解,提示可能具有治疗益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c03/5417265/9d9512bf8b03/10.1177_2329048X16632140-fig1.jpg

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