不对称铜催化环丙烯的碳镁化反应。
Asymmetric Copper-Catalyzed Carbomagnesiation of Cyclopropenes.
机构信息
The Mallat Family Laboratory of Organic Chemistry, Schulich Faculty of Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, Technion-Israel Institute of Technology, Haifa, 3200009, Israel.
出版信息
Angew Chem Int Ed Engl. 2017 Jun 6;56(24):6783-6787. doi: 10.1002/anie.201701094. Epub 2017 May 15.
The highly diastereo- and enantioselective formation of polysubstituted cyclopropanes was easily achieved through the asymmetric copper-catalyzed carbomagnesiation reaction of nonfunctionalized cyclopropene derivatives. The carbometalated species generated in situ readily undergo C-C and C-X bond-forming reactions with various electrophiles with complete retention of configuration.
通过非官能化环丙烯衍生物的不对称铜催化碳镁化反应，很容易实现高非对映选择性和对映选择性的多取代环丙烷的形成。原位生成的碳金属化物种容易与各种亲电试剂发生 C-C 和 C-X 键形成反应，并且构型完全保持。
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