Department of Chemistry, Zhejiang Normal University , 688 Yingbin Road, Jinhua 321004, China.
Org Lett. 2017 Jun 2;19(11):2929-2932. doi: 10.1021/acs.orglett.7b01162. Epub 2017 May 15.
Herein we describe a novel, visible light-induced tandem radical addition-cyclization of alkenyl aldehydes with α-bromocarbonyl compounds. A set of cyclic ketones, including indanones, cyclopentenones, 3,4-dihydronaphthalen-1(2H)-ones, and chroman-4-ones, are synthesized at room temperature with high efficiency and good functional group compatibility. It represents the first report on the catalytic 1,2-acylalkylation of unactivated alkenes.
在此，我们描述了一种新型的可见光诱导的烯基醛与α-溴代羰基化合物的串联自由基加成-环化反应。在室温下，高效且官能团兼容性良好地合成了一系列环状酮，包括茚满酮、环戊烯酮、3,4-二氢萘-1(2H)-酮和色满-4-酮。这代表了首例关于未活化烯烃的催化 1,2-酰基烷基化反应的报道。
