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可见光驱动的串联自由基环化反应合成α-羰基烷基取代的苯并咪唑并[2,1-]异喹啉-6(5)-酮衍生物

Visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-]isoquinolin-6(5)-one derivatives.

作者信息

Liu Jing, Huang Hong-Li, Wang Chen, Li Yinghua, Li Huaqiang, Hu Honggang, He Shipeng, Tang Hua, Gao Fei

机构信息

Department of Chemistry, College of Sciences, Shanghai University No. 99 Shangda Road Shanghai 200444 China.

Institute of Translation Medicine, Shanghai University Shanghai 200444 China.

出版信息

RSC Adv. 2021 Sep 1;11(47):29372-29375. doi: 10.1039/d1ra05936j.

DOI:10.1039/d1ra05936j
PMID:35479569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9040576/
Abstract

A visible-light-driven cascade radical cyclization process of -methacryloyl-2-phenylbenzimidazole has been established with α-carbonyl alkyl bromide. This protocol provides an efficient and practical method for the synthesis of various α-carbonyl alkyl-substituted benzimidazo[2,1-]isoquinolin-6(5)-ones in outstanding yields, mild reaction conditions and excellent functional group tolerance.

摘要

已利用α-羰基烷基溴建立了一种可见光驱动的α-甲基丙烯酰基-2-苯基苯并咪唑的级联自由基环化过程。该方法为合成各种α-羰基烷基取代的苯并咪唑并[2,1-a]异喹啉-6(5)-酮提供了一种高效实用的方法，产率高、反应条件温和且官能团耐受性优异。

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本文引用的文献

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Visible-Light-Promoted Cascade Radical Cyclization: Synthesis of Chroman-4-ones and Dihydroquinolin-4-ones.可见光促进的级联自由基环化反应：色满-4-酮和二氢喹啉-4-酮的合成。
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温和条件下二氟芳甲基取代的苯并咪唑并[2,1-]异喹啉-6(5)-酮的合成
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