Drew W G, Weet C R, De Rossett S E, Batt J R
Biol Psychiatry. 1980 Dec;15(6):841-58.
A battery of tests clinically employed for the estimation of auditory and visual recent memory dysfunction was administered to eight subjects having circumscribed damage to the temporal lobe. It was hypothesized that the performance of subjects with temporal lobe lesions would qualitatively resemble that of subjects intoxicated with marijuana. Where comparisons could be made, the performance of these "temporal lobe" patients paralleled the performance of subjects acutely intoxicated with known doses of delta 9-THC. Results are discussed in terms of cannabinoid actions on hippocampal functioning and, in general, support the hypothesis that the action of marijuana in the brain may focus in the hippocampal region and produce behavioral changes similar to that resulting from traumatic injury or removal of the region.
对八名颞叶有局限性损伤的受试者进行了一系列临床上用于评估听觉和视觉近期记忆功能障碍的测试。假设颞叶病变受试者的表现与大麻中毒受试者的表现会在性质上相似。在可以进行比较的地方，这些“颞叶”患者的表现与已知剂量的δ9-四氢大麻酚急性中毒受试者的表现相似。根据大麻素对海马体功能的作用对结果进行了讨论，总体而言，支持了这样一种假设，即大麻在大脑中的作用可能集中在海马体区域，并产生与该区域创伤性损伤或切除所导致的行为变化相似的行为变化。
