测定哈马丹多发性硬化症患者血清中针对巨细胞病毒和幽门螺杆菌的IgM和IgG抗体滴度，并与对照组进行比较。
Determining the IgM and IgG antibody titer against CMV and helicobacter pylori in the serum of multiple sclerosis patients comparing to the control group in Hamadan.
作者信息
Salim Masome Afiati, Eftekharian Mohammad Mahdi, Taheri Mohammad, Yousef Alikhani Mohammad
机构信息
Islamic Azad University, Hamadan Branch, Hamadan, Iran.
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
Hum Antibodies. 2017 Jul 19;26(1):23-28. doi: 10.3233/HAB-170317.
BACKGROUND
Multiple sclerosis (MS) is a chronic autoimmune disease that disables central nervous system (CNS) system. Cytomegalovirus (CMV) probably has an important role in the MS pathology. The infection with helicobacter pylori also is recognized as a protective agent against MS in female.
METHODS
Serum samples were isolated and frozen at -70∘C. The earlier mentioned anti-virus antibodies and antibacterial antibodies were quantified by Elisa kit.
RESULTS
The results showed that IgG antibody average value against cytomegalovirus in the blood of multiple sclerosis patients not only decreased but also was significant statistically (p< 0.05). IgM and IgG antibodies average value in the blood of multiple sclerosis patients against helicobacter pylori shown a statistically significant decrease (p< 0.05).
CONCLUSION
Therefore it may be considered that probably helicobacter pylori presence in the individuals especially in female can alleviate MS signs. CMV infection can intensify the symptoms in multiple sclerosis patients.
背景
多发性硬化症（MS）是一种使中枢神经系统（CNS）致残的慢性自身免疫性疾病。巨细胞病毒（CMV）可能在MS病理过程中起重要作用。幽门螺杆菌感染也被认为是女性预防MS的一种保护因素。
方法
分离血清样本并在-70°C下冷冻。通过酶联免疫吸附测定（ELISA）试剂盒对上述抗病毒抗体和抗菌抗体进行定量分析。
结果
结果显示，多发性硬化症患者血液中抗巨细胞病毒IgG抗体平均值不仅降低，而且具有统计学意义（p<0.05）。多发性硬化症患者血液中抗幽门螺杆菌IgM和IgG抗体平均值有统计学意义的下降（p<0.05）。
结论
因此，可以认为个体尤其是女性体内存在幽门螺杆菌可能会减轻MS症状。CMV感染会加重多发性硬化症患者的症状。
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