Kapadia Vishal S, Wyckoff Myra H
Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Front Pediatr. 2017 May 1;5:97. doi: 10.3389/fped.2017.00097. eCollection 2017.
Epinephrine use in the delivery room for resuscitation of the newborn is associated with significant morbidity and mortality. Evidence for optimal dose, timing, and route of administration of epinephrine during neonatal resuscitation comes largely from extrapolated adult or animal literature. In this review, we provide the current recommendations for use of epinephrine during neonatal resuscitation and also the evidence behind these recommendations. In addition, we review the current proposed mechanism of action of epinephrine during neonatal resuscitation, review its adverse effects, and identify gaps in knowledge requiring urgent research.
在产房使用肾上腺素对新生儿进行复苏与显著的发病率和死亡率相关。新生儿复苏期间肾上腺素最佳剂量、给药时机和给药途径的证据很大程度上来自推断的成人或动物文献。在本综述中，我们提供了新生儿复苏期间使用肾上腺素的当前建议以及这些建议背后的证据。此外，我们回顾了肾上腺素在新生儿复苏期间目前提出的作用机制，综述了其不良反应，并确定了需要紧急研究的知识空白。
