Lurz Eberhard, Aeschbacher Eliane, Carman Nicholas, Schibli Susanne, Sokollik Christiane, Simonetti Giacomo D
Division of Pediatric Gastroenterology, Hepatology and Nutrition, University Children's Hospital, Inselspital, University of Bern, Bern, Switzerland.
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Hospital for Sick Children, Toronto, ON, Canada.
Eur J Pediatr. 2017 Jul;176(7):983-987. doi: 10.1007/s00431-017-2927-7. Epub 2017 May 15.
In adults with inflammatory bowel disease (IBD), the incidence of cardiovascular events is increased, leading to long-term morbidity. Arterial stiffness (AS) measured by pulse wave velocity (PWV) is a validated early precursor of cardiovascular disease (CVD), and measurement of PWV was shown to be a feasible test in children. The aim of this study was to assess AS in children with IBD. In this prospective study, we determined PWV between the carotid and femoral artery (PWV) in 25 children and adolescents with IBD (11 females, median age 14.1 years, median disease duration 2.8 years). The majority (68%) of the subjects were in clinical remission, and 48% received anti-tumor necrosis factor alpha (TNFα) treatment. AS was not increased in this cohort of children and adolescents with IBD, who did not have signs of cardiovascular disease, such as arterial hypertension.
PWV seems to be normal in children with IBD in remission or with mild disease activity. Larger studies should assess its potential role as a valid and non-invasive follow-up marker in children with IBD, to avoid cardiovascular complications. What is Known : • Inflammatory bowel disease (IBD) is a risk factor of cardiovascular disease (CVD). • Pulse wave velocity (PWV) measurement is the current gold standard to assess arterial stiffness (AS), which is an early predictor of CVD. What is New: • This is the first study using PWV measurements to determine AS in children with IBD. • In children with IBD in remission or only mild disease activity AS is not increased.
在患有炎症性肠病（IBD）的成年人中，心血管事件的发生率会升高，导致长期发病。通过脉搏波速度（PWV）测量的动脉僵硬度（AS）是经证实的心血管疾病（CVD）早期先兆，并且PWV测量在儿童中被证明是一项可行的检测。本研究的目的是评估IBD患儿的AS。在这项前瞻性研究中，我们测定了25例IBD患儿和青少年（11名女性，中位年龄14.1岁，中位病程2.8年）的颈股动脉脉搏波速度（PWV）。大多数（68%）受试者处于临床缓解期，48%接受抗肿瘤坏死因子α（TNFα）治疗。在这组没有心血管疾病体征（如动脉高血压）的IBD患儿和青少年中，AS并未升高。
处于缓解期或疾病活动度较轻的IBD患儿的PWV似乎正常。规模更大的研究应评估其作为IBD患儿有效且非侵入性随访标志物的潜在作用，以避免心血管并发症。已知信息：• 炎症性肠病（IBD）是心血管疾病（CVD）的危险因素。• 脉搏波速度（PWV）测量是评估动脉僵硬度（AS）的当前金标准，AS是CVD的早期预测指标。新发现：• 这是第一项使用PWV测量来确定IBD患儿AS的研究。• 处于缓解期或仅疾病活动度较轻的IBD患儿的AS并未升高。
