Yazgan Serpil, Arpaci Dilek, Celik Haci Ugur, Isik Irem
Department of Ophthalmology, Medical Faculty, GözHastaliklari Polikiliniği, Bulent Ecevit University, C Blok, Kat 1, Esenköy, Kozlu, Zonguldak, Turkey.
Endocrinology Division, Department of Internal Medicine, Medical Faculty, Bulent Ecevit University, Zonguldak, Turkey.
Int Ophthalmol. 2018 Apr;38(2):617-625. doi: 10.1007/s10792-017-0500-z. Epub 2017 May 15.
To evaluate macular volume, retinal nerve fiber layer, and macular and peripapillary choroidal thickness in acromegaly patients.
In this prospective, case-control study, 31 patients with acromegaly and 32 healthy subjects were recruited. Only right eyes were evaluated. Macular choroidal thickness (CT) was measured at three points, peripapillary CT was measured at eight points, and macular volume was measured at nine areas in the central 6 mm circle zone by spectraldomain optical coherence tomography (OCT). Retinal nerve fiber layer (RNFL) was measured automatically at six segments by OCT.
The mean macular and peripapillary CT at all measuring points were significantly higher in acromegaly group (p < 0.05). RNFL thicknesses were significantly higher in acromegaly except for temporal segment (p < 0.05). The mean total, inferior and superior retinal volume of the macula were significantly higher in acromegaly group (p < 0.001), whereas there was no statistically difference was seen in retinal volume of temporal and nasal macular area between the two groups (p > 0.05).
The macular and peripapillary choroidal thickness, retinal nerve fiber layer, and total retinal volume of the macula were significantly higher in acromegaly patients. Increased choroidal thickness may cause different macular pathologies such as choroidal neovascularization. RNFL results may be important in acromegaly patients with glaucoma, especially if the progress of glaucoma is monitored by OCT.
评估肢端肥大症患者的黄斑体积、视网膜神经纤维层以及黄斑和视乳头周围脉络膜厚度。
在这项前瞻性病例对照研究中，招募了31例肢端肥大症患者和32名健康受试者。仅对右眼进行评估。通过光谱域光学相干断层扫描（OCT）在三个点测量黄斑脉络膜厚度（CT），在八个点测量视乳头周围CT，并在中央6毫米圆形区域的九个区域测量黄斑体积。通过OCT自动测量视网膜神经纤维层（RNFL）的六个节段。
肢端肥大症组所有测量点的平均黄斑和视乳头周围CT均显著更高（p<0.05）。除颞侧节段外，肢端肥大症患者的RNFL厚度显著更高（p<0.05）。肢端肥大症组黄斑的平均总视网膜体积、下方和上方视网膜体积显著更高（p<0.001），而两组之间颞侧和鼻侧黄斑区域的视网膜体积无统计学差异（p>0.05）。
肢端肥大症患者的黄斑和视乳头周围脉络膜厚度、视网膜神经纤维层以及黄斑的总视网膜体积显著更高。脉络膜厚度增加可能导致不同的黄斑病变，如脉络膜新生血管形成。RNFL结果对于患有青光眼的肢端肥大症患者可能很重要，特别是如果通过OCT监测青光眼的进展。
