Okazaki M, Ohmae H
Department of Dental Technology, Osaka University Faculty of Dentistry, Japan.
Biomaterials. 1988 Jul;9(4):345-8. doi: 10.1016/0142-9612(88)90031-2.
Well-crystallized hydroxyapatite was synthesized at 80 degrees C and pH 7.4, and mixed as filler with 2.2'(4-methacryloxydiethoxyphenyl) propane. BPO and DHPT were used as polymerization initiators. The compressive strength and Knoop hardness of the apatite composite resins increased with the increase of apatite content, and approached a plateau above an apatite-resin ratio (Ap/R) of 1. The thermal expansion coefficient of the composite with apatite-resin ratio Ap/R = 1 was almost equal to that of teeth. In tooth cavities, the composites seemed to adhere well to enamel without a bonding agent. The biocompatibility of the composites implanted hypodermically into rats appeared to improve with the increase of apatite content, and implants showed no significant inflammation after 1 wk and 4 wk.
在80摄氏度和pH值7.4的条件下合成了结晶良好的羟基磷灰石，并将其作为填料与2,2'-(4-甲基丙烯酰氧基二乙氧基苯基)丙烷混合。使用BPO和DHPT作为聚合引发剂。磷灰石复合树脂的抗压强度和努氏硬度随着磷灰石含量的增加而增加，并且在磷灰石与树脂的比例（Ap/R）大于1时接近平稳状态。磷灰石与树脂比例Ap/R = 1的复合材料的热膨胀系数几乎与牙齿的热膨胀系数相等。在牙洞中，复合材料在没有粘结剂的情况下似乎能很好地粘附于牙釉质。皮下植入大鼠体内的复合材料的生物相容性似乎随着磷灰石含量的增加而提高，植入物在1周和4周后未显示出明显的炎症。
