瞬时受体电位通道与阿尔茨海默病

TRPC Channels and Alzheimer's Disease.

作者信息

Lu Rui, He Qian, Wang Junfeng

机构信息

Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China.

Research and Development of Biogen, 225 Binney Street, Cambridge, MA, 02142, USA.

出版信息

Adv Exp Med Biol. 2017;976:73-83. doi: 10.1007/978-94-024-1088-4_7.

DOI:10.1007/978-94-024-1088-4_7

PMID:28508314

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. The "amyloid hypothesis" is one of the predominant hypotheses for the pathogenesis of AD. Besides, tau protein accumulation, calcium homeostasis disruption, and glial cell activation are also remarkable features in AD. Recently, there are some reports showing that TRPC channels may function in AD development, especially TRPC6. In this chapter, we will discuss the evidence for the involvement of TRPC channels in Alzheimer's disease and the potential of therapeutics for AD based on TRPC channels.

摘要

阿尔茨海默病（AD）是世界上最常见的神经退行性疾病。“淀粉样蛋白假说”是AD发病机制的主要假说之一。此外，tau蛋白积累、钙稳态破坏和胶质细胞活化也是AD的显著特征。最近，有一些报道表明瞬时受体电位通道（TRPC通道）可能在AD发展中发挥作用，尤其是TRPC6通道。在本章中，我们将讨论TRPC通道参与阿尔茨海默病的证据以及基于TRPC通道的AD治疗潜力。