T细胞去除的骨髓移植后继发性爱泼斯坦-巴尔病毒相关淋巴瘤的长期缓解
Prolonged remission of Epstein-Barr virus associated lymphoma secondary to T cell-depleted bone marrow transplantation.
作者信息
Lyttelton M P, Browett P J, Brenner M K, Norton J D, Kolman J L, McGee J O, Hamilton-Dutoit S, Hoffbrand A V, Prentice H G
机构信息
Department of Haematology, Royal Free Hospital, London, UK.
出版信息
Bone Marrow Transplant. 1988 Nov;3(6):641-6.
PMID:2850832
Abstract
High grade non-Hodgkin's lymphoma developed 42 days after allogeneic T cell-depleted bone marrow transplantation (BMT) for idiopathic aplastic anaemia. DNA hybridization studies confirmed clonality and incorporation of Epstein-Barr virus (EBV) genome. Prolonged remission followed low dose chemotherapy, local radiotherapy and early withdrawal of cyclosporin.
摘要
一名特发性再生障碍性贫血患者在接受去除T细胞的异基因骨髓移植（BMT）42天后发生了高级别非霍奇金淋巴瘤。DNA杂交研究证实了克隆性以及爱泼斯坦-巴尔病毒（EBV）基因组的整合。低剂量化疗、局部放疗以及早期停用环孢素后获得了长期缓解。
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