Nazarali A J, Gutkind J S, Correa F M, Saavedra J M
Unit on Preclinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892.
Brain Res. 1988 Dec 13;475(1):134-40. doi: 10.1016/0006-8993(88)90206-5.
Spontaneously hypertensive rats (SHR) showed lower brain ANP binding density when compared with normotensive Wistar-Kyoto (WKY) rats. In the WKY, angiotensin converting enzyme inhibitor, enalapril (25 mg/kg, p.o. for 14 days), decreased the number of ANP binding sites selectively in the subfornical organ and area postrema. Conversely, enalapril increased ANP binding density in the SHR, but only in the area postrema. Enalapril has central effects on ANP binding sites, specific to the circumventricular organs.
与正常血压的Wistar-Kyoto（WKY）大鼠相比，自发性高血压大鼠（SHR）的脑心钠肽（ANP）结合密度较低。在WKY大鼠中，血管紧张素转换酶抑制剂依那普利（25毫克/千克，口服，持续14天）可选择性降低穹窿下器官和最后区的ANP结合位点数量。相反，依那普利可增加SHR的ANP结合密度，但仅在最后区。依那普利对ANP结合位点有中枢作用，且对室周器官具有特异性。
