Morales Adriana, Perlmann Eduardo, Abelha Aline Nayara Vechiato, Levy Carlos Emilio, de Goes Ana Carolina Almeida, Safatle Angélica M V
Clínica de Oftalmologia Veterinária Oftalmopet, Valinhos, SP, Brazil.
Clínica Veterinária Vetmasters, Setor de Oftalmologia, São Paulo, SP, Brazil.
Vet Ophthalmol. 2018 May;21(3):305-311. doi: 10.1111/vop.12482. Epub 2017 May 15.
Parasitic agents have been associated with keratitis, but a diagnosis of parasitic keratitis has not been commonly made in domestic animals. The purpose of this study was to describe the clinical and histopathological findings in seven dogs with chronic keratitis caused by microfilariae diagnosed in Brazil. All dogs presented with superficial corneal opacities of varying degrees affecting the perilimbal and central regions of the cornea, with other opaque areas appearing as crystalline deposits and corneal vascularization. The lesions were bilateral and were associated with mild-to-moderate conjunctival hyperemia. There was no history of blepharospasm or pruritus, and no subjects presented with epithelial erosions. Corneal biopsy revealed free microfilariae in the corneal stroma, with varying degrees of inflammation and collagen fiber destruction. The microfilariae were also found in skin lesions by skin snip technique. No adult worms were found in these dogs, and no dogs were on heartworm preventative before diagnosis. Monthly doses of oral ivermectin improved ocular and dermal lesions. One dog showed complete remission with the treatment. The species of the microfilariae was not identified.
寄生虫病原体与角膜炎有关，但在家畜中，寄生性角膜炎的诊断并不常见。本研究的目的是描述在巴西诊断出的7例由微丝蚴引起的慢性角膜炎犬的临床和组织病理学发现。所有犬均出现不同程度的浅表角膜混浊，累及角膜缘和中央区域，其他混浊区域表现为结晶状沉积物和角膜血管化。病变为双侧性，伴有轻度至中度结膜充血。无眼睑痉挛或瘙痒病史，且无动物出现上皮糜烂。角膜活检显示角膜基质中有游离的微丝蚴，伴有不同程度的炎症和胶原纤维破坏。通过皮肤剪片技术在皮肤病变中也发现了微丝蚴。这些犬未发现成虫，且在诊断前没有犬使用过预防心丝虫的药物。每月口服伊维菌素可改善眼部和皮肤病变。1只犬经治疗后完全缓解。微丝蚴的种类未确定。
