Kim Jin Soo, Lee Seul Gi, Kang Young Jin, Kwon Taeg Kyu, Nam Ju-Ock
a Department of Food Science and Biotechnology , Kyungpook national University , Daegu , Korea.
b Department of Pharmacology , College of Medicine, Yeungnam University , Daegu , Korea.
Nat Prod Res. 2018 May;32(10):1216-1219. doi: 10.1080/14786419.2017.1326039. Epub 2017 May 16.
Kahweol, a compound from Coffea arabica, possesses antioxidant, anti-inflammatory, and antitumour properties. However, an anti-adipogenic effect has not yet been reported. In this study, we have shown that kahweol has an anti-adipogenic effect on 3T3-L1 adipocytes. Kahweol significantly inhibited the differentiation of intracellular lipid accumulation in 3T3-L1 adipocytes, without being cytotoxic. It also downregulated the expression of adipogenesis-related gene, including an adipocytokine, adiponectin. This anti-adipogenic effect stems from an ability to inhibit key adipogenic regulators, including PPARγ and C/EBPα. These results demonstrate that kahweol significantly inhibits the differentiation of 3T3-L1 cells, and suggest that it has potential as a novel anti-obesity treatment.
咖啡豆醇是一种来自阿拉伯咖啡的化合物，具有抗氧化、抗炎和抗肿瘤特性。然而，其抗脂肪生成作用尚未见报道。在本研究中，我们发现咖啡豆醇对3T3-L1脂肪细胞具有抗脂肪生成作用。咖啡豆醇显著抑制3T3-L1脂肪细胞内脂质积累的分化，且无细胞毒性。它还下调了脂肪生成相关基因的表达，包括一种脂肪细胞因子脂联素。这种抗脂肪生成作用源于其抑制关键脂肪生成调节因子（包括PPARγ和C/EBPα）的能力。这些结果表明，咖啡豆醇显著抑制3T3-L1细胞的分化，并提示其具有作为新型抗肥胖治疗药物的潜力。
