Bhandarkar Nikhil S, Mouatt Peter, Majzoub Marwan E, Thomas Torsten, Brown Lindsay, Panchal Sunil K
Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, Australia.
Southern Cross Plant Science, Southern Cross University, Lismore, NSW 2480, Australia.
Pathogens. 2021 Oct 22;10(11):1369. doi: 10.3390/pathogens10111369.
Waste from food production can be re-purposed as raw material for usable products to decrease industrial waste. Coffee pulp is 29% of the dry weight of coffee cherries and contains caffeine, chlorogenic acid, trigonelline, diterpenes and fibre. We investigated the attenuation of signs of metabolic syndrome induced by high-carbohydrate, high-fat diet in rats by dietary supplementation with 5% freeze-dried coffee pulp for the final 8 weeks of a 16-week protocol. Coffee pulp decreased body weight, feed efficiency and abdominal fat; normalised systolic blood pressure, left ventricular diastolic stiffness, and plasma concentrations of triglycerides and non-esterified fatty acids; and improved glucose tolerance in rats fed high-carbohydrate, high-fat diet. Further, the gut microbiota was modulated with high-carbohydrate, high-fat diet and coffee pulp supplementation and 14 physiological parameters were correlated with the changes in bacterial community structures. This study suggested that coffee pulp, as a waste from the coffee industry, is useful as a functional food for improving obesity-associated metabolic, cardiovascular and liver structure and function, and gut microbiota.
食品生产过程中的废弃物可以重新用作可利用产品的原材料，以减少工业废料。咖啡果肉占咖啡樱桃干重的29%，含有咖啡因、绿原酸、胡芦巴碱、二萜类化合物和纤维。在一项为期16周的实验方案的最后8周，我们通过在大鼠饮食中添加5%的冻干咖啡果肉，研究了高碳水化合物、高脂肪饮食诱导的代谢综合征症状的缓解情况。咖啡果肉降低了大鼠的体重、饲料效率和腹部脂肪；使收缩压、左心室舒张硬度以及甘油三酯和非酯化脂肪酸的血浆浓度恢复正常；并改善了高碳水化合物、高脂肪饮食喂养的大鼠的葡萄糖耐量。此外，高碳水化合物、高脂肪饮食以及补充咖啡果肉对肠道微生物群进行了调节，14个生理参数与细菌群落结构的变化相关。这项研究表明，作为咖啡产业废弃物的咖啡果肉，可用作功能性食品，以改善与肥胖相关的代谢、心血管和肝脏结构与功能，以及肠道微生物群。
